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STAT+: AbbVie skin disorder drug succeeds in late-stage trial, but results miss market expectations

By Jonathan Wosen · Via STAT Health · Published by Everything Blog

In short

AbbVie's experimental drug for hidradenitis suppurativa, luttikizumab, showed a 75% or greater reduction in inflamed bumps and abscesses in 31.4% of participants compared to 23.4% in the placebo group after 16 weeks. It met eight secondary endpoints, including improvements in skin pain and flares, and was generally safe and well tolerated with similar adverse event rates between the placebo and treatment groups.

Key points

AbbVie's experimental drug for hidradenitis suppurativa showed promising results in a lat…: AbbVie's experimental drug for hidradenitis suppurativa showed promising results in a late-stage trial.
It reduced inflamed bumps and abscesses by 75% or more in 31.4% of participants.: It reduced inflamed bumps and abscesses by 75% or more in 31.4% of participants.
It met eight secondary endpoints, including improvements in skin pain and flares.: It met eight secondary endpoints, including improvements in skin pain and flares.

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AbbVie reported on Thursday that an experimental therapy for hidradenitis suppurativa, a chronic skin condition, succeeded in a late-stage trial but missed market expectations, leaving experts doubtful the drug can compete with the current standard of care.

In the Phase 3 Intrepid trial, which enrolled 1,400 patients with moderate-to-severe hidradenitis suppurativa, 31.4% of participants given weekly injections of AbbVie’s therapy, lutikizumab, reported a 75% or greater reduction in the number of inflamed bumps and abscesses across their skin, compared to 23.4% of those in the placebo group after 16 weeks. This measure was the study’s primary endpoint.

The company also reported that the drug met eight secondary endpoints, including improvements in skin pain and flares. Lutikizumab was generally safe and well tolerated, with adverse event rates that were nearly identical between the placebo and treatment groups.

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Original source: www.statnews.com

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Key Points

AbbVie's experimental drug for hidradenitis suppurativa showed promising results in a lat…: AbbVie's experimental drug for hidradenitis suppurativa showed promising results in a late-stage trial.
It reduced inflamed bumps and abscesses by 75% or more in 31.4% of participants.: It reduced inflamed bumps and abscesses by 75% or more in 31.4% of participants.
It met eight secondary endpoints, including improvements in skin pain and flares.: It met eight secondary endpoints, including improvements in skin pain and flares.

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AI Analysis

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Positive

In short

Key Points

AbbVie's experimental drug for hidradenitis suppurativa showed promising results in a lat…: AbbVie's experimental drug for hidradenitis suppurativa showed promising results in a late-stage trial.
It reduced inflamed bumps and abscesses by 75% or more in 31.4% of participants.: It reduced inflamed bumps and abscesses by 75% or more in 31.4% of participants.
It met eight secondary endpoints, including improvements in skin pain and flares.: It met eight secondary endpoints, including improvements in skin pain and flares.

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Health

Was this summary useful?

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STAT+: AbbVie skin disorder drug succeeds in late-stage trial, but results miss market expectations

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