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Merck tops quarterly estimates, hikes profit outlook as new form of Keytruda shows strength

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In short

The company's quarterly outperformance was anchored by flagship cancer therapy Keytruda, which delivered $8.60 billion in sales against analyst projections of $7.73 billion. Portfolio diversification also bolstered top-line gains, highlighted by Gardasil vaccine revenues reaching roughly $2 billion alongside a 93% surge from lung treatment Winrevair. Even after absorbing a $400 million charge tied to a licensing partnership with Chinese drugmaker SciBrunch, leadership raised its full-year earnings expectations.

Key points

  • Uptake of Keytruda Qlex is crucial for migrating patients away from intravenous infusions…: Uptake of Keytruda Qlex is crucial for migrating patients away from intravenous infusions before crucial patent protections lapse in 2028.
  • Accelerated demand for Winrevair and Gardasil demonstrates expanding revenue streams outs…: Accelerated demand for Winrevair and Gardasil demonstrates expanding revenue streams outside of the central oncology franchise.
  • Strong underlying margins enabled management to raise full-year profit projections despit…: Strong underlying margins enabled management to raise full-year profit projections despite absorbing a substantial licensing fee for SciBrunch.

Sources checked by our analysis pipeline: 1

Merck on Thursday topped third-quarter estimates and hiked its adjusted profit outlook, as its immunotherapy Keytruda, including a newer injectable form of the drug, showed stronger-than-expected sales.

The pharmaceutical giant now expects adjusted earnings to be between $2.77 and $2.82 per share. That adjusted profit outlook is up from a previous range of $2.66 to $2.76 per share. The guidance now includes a one-time charge of $400 million, or 12 cents per share, related to its licensing agreement with the Chinese cancer drugmaker SciBrunch

Merck also narrowed the low end of its 2026 revenue guidance, now expecting sales between $66.8 billion and $67.3 billion. That compares to a previous outlook of $66.3 billion to $67.3 billion.

The company has been on a deal spree as it races to offset generic competition for Keytruda after key patents begin expiring in 2028.

Merck is also positioning the new form of the drug, Keytruda Qlex, as a cornerstone of its growth strategy. The goal is to transition patients from the original intravenous version to Qlex, considered a more convenient under-the-skin injection. This strategy…

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