New formulation helps RNA vaccines withstand high temperatures
In short
MIT researchers have developed a new formulation for RNA vaccines that can withstand high temperatures, overcoming a key limitation of these vaccines. This breakthrough was made possible through the use of an AI algorithm, which helped identify the optimal excipients to stabilize lipid nanoparticles (LNPs) used to deliver mRNA vaccines. The new formulation allows vaccines to remain stable even when stored at room temperature for up to a year or at nearly 100 degrees Fahrenheit for two months, generating a strong immune response similar to Moderna's vaccine. This development could enable the widespread distribution of vaccines, including microneedle patches, which could release the vaccine o…
Key points
- The new formulation helps RNA vaccines withstand high temperatures.: The new formulation helps RNA vaccines withstand high temperatures.
- MIT researchers used an AI algorithm to identify optimal excipients.: MIT researchers used an AI algorithm to identify optimal excipients.
- The formulation allows vaccines to remain stable for up to a year at room temperature.: The formulation allows vaccines to remain stable for up to a year at room temperature.